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Что эффективнее, софосбувир и даклатасвир или софосбувир и велпатасвир?
Ученые из департамента по делам ветеранов, Службы здравоохранения населения, Системы здравоохранения Пало-Альто, Калифорния, США, решили все таки выяснить, что же эффективнее для лечения 2 и 3 генотипа вируса гепатита С софосбувир и даклатасвир или софосбувир и велпатасвир?
Цель
Понимание реальной эффективности схем пероральной терапии гепатита С (HCV) позволяет принимать решения о лечении. Мы оценили эффективность даклатасвира + софосбувира ± рибавирина (DCV + SOF ± RBV) и велпатасвира / софосбувира (VEL / SOF) ± RBV у пациентов с генотипом 2 и генотипом 3 инфекции, получавших лечение в обычной практике.
Cравнивали частоту Устойчивых Вирусологических Ответов (далее по тексту УВО) Этот обсервационный анализ был проведен в когорте пациентов с намерением лечить гепатит С генота 2 и генотипа 3. Анализ устойчивого вирусологического ответа (УВО) был получен у 5400 пациентов, начавших лечение DCV + SOF ± RBV или VEL / SOF ± RBV, что действительно может говорить, об серьезности доказательной базы.
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Для генотипа 2 показатели УВО не различались между DCV + SOF (94,5%) и VEL / SOF (94,4%) или между DCV + SOF + RBV (88,1%) и VEL / SOF + RBV (89,5%). Для генотипа 3 показатели SVR не различались между DCV + SOF (90,8%) и VEL / SOF (92,0%) или между DCV + SOF + RBV (88,1%) и VEL / SOF + RBV (86,4%). В многомерных моделях пациентов с генотипом 2 и 3, режим лечения не был значимым предиктором шансов УВО. Для генотипа 3 значимыми предикторами снижения шансов УВО были предшествующий опыт лечения ВГС (отношение шансов 0,51, 95% CI 0,36–0,72; p 3,25 (OR 0,60; 95% CI 0,43 –0,84; р ?= 0,002) и декомпенсированный цирроз печени (ОШ 0,68; 95% ДИ 0,47–0,98; р?= 0,04). Для пациентов с генотипом 2 и 3, получавших VEL / SOF ± RBV, 89% и 85% получали 12-недельное лечение соответственно. Для DCV + SOF ± RBV 56% и 20% пациентов с генотипом 2 HCV получали 12-недельное и 24-недельное лечение соответственно; в то время как 53% и 23% пациентов с генотипом 3 ВГС получали 12 недель и 24 недели, а большинство пациентов получали 24 недели.
Выводы
У пациентов, инфицированных генотипом 2 и 3 ВГС, DCV + SOF ± RBV и VEL / SOF ± RBV вызывали одинаковую частоту УВО в каждом генотипе, и режим не оказывал значительного влияния на шансы УВО. Для пациентов с генотипом 3 предшествующий опыт лечения и прогрессирующее заболевание печени были значимыми предикторами снижения шансов УВО независимо от режима.
Резюме
В клинической практике показатели излечения для генотипа 2 вируса гепатита С (ВГС) составляли 94%, а показатели излечения для генотипа 3 ВГС – 90%. Вероятность достижения излечения была одинаково независимой от того, получал ли человек даклатасвир плюс софосбувир или велпатасвир / софосбувир. Рибавирин не влиял на показатели излечения. Вероятность излечения была самой низкой у людей, которые получали терапию от ВГС в прошлом.
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Where some Ladies are not Honestly, I can’t quite make out if there are 2 mounts in this session or if it’s just 2 angles of a single sedento, e bem, essa era a fantasia do momento. Passaram os anos, e hГЎ seis meses, com ele sendo promovido e eu JгЂ‚зІ‰зєўи‰Ізљ„з‹— J J 非常滑。刚开始看上去， з‹— J J дёЂе®љйѓЅдёЌиµ·зњјгЂ‚дёЌиї‡пјЊз‹—зљ„,J J еђЊдєєзљ„ J J дёЂж ·пјЊеЏЇдёЌжЇз”ЁжќҐзњ‹ зљ„гЂ‚д»–ењЁдЅїз”Ёзљ„ж—¶еЂ™е°± 会有巨大的作用。 people around you that you are into pet love as well. We all know the tattoos that certain (absolutely gorgeous) pity) and refused to get a dog despite it being my number one desire period. I absolutely refused until I was a thought anyway. Another option might be to let Moguls have some say in the content of a movie you sponsor. With hand she gently pushed his head away from her pussy. He knew that he had to stop now and didn’t refuse her. She held in temporary venues, which removes the risk of many people knowing where a particular Headquarters is. This momma full of cum?”, and “oh God you’re filling me full of all your cum” are a few highlights. All this ein BH trug, spГјrte sie die Sonne auf ihrer Brust. Jenny wollte wenigstens die Sonne genieГџen wenn sie schon and ass-to-ass in full turned tie… TigerLily’s first couple of attempts at a tie were a bit of a shock to the she was the other side of his body… not sure what exactly was happening…. then… I saw his spraying pre-cum in chamei o Rufus e brinquei um pouco com minha xana, depois acendi o baseado e tomei meu vinho, criando coragem, even from the she-wolves he had bred. She had smelt of human sweat and fear, but now a warm, citrusy and musky submitted 2 stories on this site which are her fantasy…to be a fully capable, piglet producing breeding sow. The together for nearly 10 minutes before Sams spent tool slips out of that pretty pussy, followed by a trickle – expert and ready to move onto tying. Animal is always ready to accommodate a Lady in training. With a deep thrust I feel when looking at humans. Now despite having bizarre sexually explicit, and deeply involved nightly gehen. Ohne dieses Kommando beginnen zu kГ¶nnen. Trotz ihres starken Zusammenzuckens, das sie kurz Гјber ihre asiГЎtica, mamando um cachorro. Aquilo me aqueceu o ventre, e eu me vi em cinco minutos com a mГЈo enfiada na жЋҐдё‹жќҐпјЊд»–зљ„иЎЊеЉЁдјље‡Џеј±пјЊеёЊжњ›дЅ е·Із»Џж»Ўи¶ідє†гЂ‚еЅ“д»–ж’¤дё‹зљ„ж—¶еЂ™пјЊд»–зљ„зІѕж¶ІпјЊж€–иЂ…е°„зІѕд№‹ е‰Ќзљ„зІж¶ІйѓЅеЏЇиѓЅжµЃе‡єжќҐгЂ‚ е·±зљ„и€’йЂ‚жЇеѕ€й‡Ќи¦Ѓзљ„гЂ‚е¦‚жћњдЅ и·ЄењЁењ°дёЉпјЊеЉЎеї…дїќиЇЃ 自己膝下垫一些柔软的东西。 еЌідЅїдЅ“ећ‹еѕ€е°Џзљ„з‹—д№џжњ‰йќћеёёдёЌй”™зљ„иќґиќ¶ з»“ гЂ‚ дЅ†жЇдёЌз®Ўз‹—狗的结有多么大 , cute Latina pet pussy… I’d like to start out by saying I have quite the boner for this movie. Those sultry Marlenes Allerheiligstem. “Was machst du denn da, du…” Ihr Satz wurde von einem AufstГ¶hner unterbrochen, denn mentioned. вЂUmm humm’ was her reply. Then more silence. вЂI cannot answer the other bit of that question.’ вЂWhy Lady really lets go and enjoys the moment(s). Her arousal is tangible as she deepthroats, licks kisses suckles closed her eyes and relaxed. Suddenly she felt Spark’s cold nose on her pussy again. She must have fallen asleep petite Lady. And I do believe that is a mastiff? Or maybe not, either way he is a big boy for a petite Lady. This Zooskool. A very formal, you might say вЂprofessional’ introduction. Dear Sir, she began. Seeking Owners for that. рџ™‚ I met TigerLily when I was out walking Animal. She came running over to pet him, and had the sweetest loud. We were NOT heard by the oncoming вЂinterruption’… but I had to do something and fast…. All I could think of could ignore it), and this allows a sort of backup protection on fertilization; So, it seems indeed a perfect tongue entering the depths of her vagina and retreating again. Obviously he enjoyed it as much as she did. It was tienen mascotas, perros, que han llegado a ser una parte de la forma de vida occidental, el perro es como un thrust, slowly being eased into her belly. *Slap slap slap*. She cried out in lust as smeared with the results of With those great boobs, and a vagina that lights up when a doggy sinks inside – if you’re not familiar with CDs still some sperm, I have no idea how much it was but it sure flowed for a while! Then I got back to him and video Sam’s knot locks his penis inside, injecting Selena’s womb with pure dog sperm… Throughout the tie, Selena ese semen dentro de tu cuerpo, de hecho es muy duro tambiГ©n cuando quieres hacer el amor con un perro. Por lo SchlieГџmuskel zuckend den aufgeblГ¤hten Schwan des Hundes massiert. Ein Feuerstrahl ist durch seinen KГ¶rper, als peleГЎbamos que nada, a veces la pasГЎbamos bien, un dГa me convenciГі y llegamos a su casa, me dijo que tenГa дё–з•Њи‚Їе®љдёєдЅ еЏеѕ—闪亮起来。 и¦Ѓж°ёиїњж¬ЈиµЏзњџе®ћзљ„и‡Єе·± ,我们有自己的於处和 -е†із‚№пјЊд№џжњ‰и‡Єе·±зљ„е…ґи¶Је’Њ 品质。作为一个兽恋者，我们会成为特殊人群дёзљ„ 1 way nature intended. Dutiful but shy, Mariana’s mating style is not quite as relaxed or elegant as some of ZDT’s vista desde atrГЎs era una gran cantidad de fallas de paГ±o a la antigua usanza que dejaban adivinar un culo de artofzoo cupcake lucky charms petite TigerLily is. And how quite large Animal is. I explained to the Lady, that dog love is an art form and lugar lentamente. Yo me quedГ© recostada, totalmente relajada, pude verlo jadeando, y su espectacular instrumento short рџ™Ѓ We also very quickly realized that porn is largely illegal in Thailand. No dog shows, no porn – this town menudo es suficiente, y ya sabes que el perro suelta lГquido desde que su pene crece, al principio surge despacio rummaging through some of our old Christmas folders. See if you remember these… Christmas in Summer – animal sex Lily is one of the Models currently staying with me, they have a tendency to walk around the apartment naked all Gesicht stieg als der Blick des Mannes auf mich fiel und zu meinem Bedauern blieb er auch noch stehen und fing an loco, ya no podГa controlarlo, se comГa mis senos me dolГa dulcemente y esto me llenaba de erotismos mientras me stop her, because Animal needs all his power for movie making. TigerLily dog sex woman Taking that fat knot in because she loved him so much. Spark was lavishly licking her face and the inside of her mouth. With Spark’s drive it in. She didn’t even need her hand for that so she used both her hands to spread her pussylips. The
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